Cohort Teams

NeuroRadVision - Team 2

NeuroRadVision – 2016

NeuroRadVision™ technology is a decision support software that constitutes a set of advanced computerized image analysis and interpretation tools for characterization of brain tumor lesions.

Business Thesis: NeuroRad Vision helps neuroradiologists distinguish brain tumor recurrences from benign treatment effects (sensitivity = 95%) and therefore reduces unnecessary biopsies (by >50%) and improves patient care.

EL: Prateek Prasanna, MS, PhD candidate, BME, Case Western Reserve University
Co-EL: Gagandeep Singh, MD, MBA candidate, Case Western Reserve University
PI: Pallavi Tiwari, PhD, Assistant Professor, BME, Case Western Reserve University
Mentor: Steve Fening, PhD, Director, Case Coulter Program
Mentor: Anant Madabhushi, PhD, Professor, BME, Case Western Reserve University

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GPN Therapeutics - team 4 of the I-Corps 2016 program. (Christina Paolucci, photographer).

GPN Therapeutics – 2016

A novel protein therapy (Osteaoactivin “OA”) to regenerate bone that will provide enhanced relief from those patients suffering from trauma induced bone fractures requiring bone grafting.

Business Thesis: An effective orthobiologic to accelerate bone regeneration in cases of posterior lumbar interbody spinal fusion (L4-S1) to help spine surgeons and hospital administrators reduce operative and post-operative timing (1-2 hrs/procedure), costs ($1-10K/procedure) and patient recovery time by 33%.

EL: Greg Sondag, PhD, Postdoctoral Fellow, Northeast Ohio Medical University
Co-EL: Fouad Moussa, BS, Graduate Student, Kent State University/NEOMED
PI: Fayez Safadi, PhD, Professor and Ohio Research Scholar, Northeast Ohio Medical University
Mentor: Elliot Reed, JD, Director, REDIzone Program Manager, Northeast Ohio Medical University

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EFOST-Team 10

EFOST – 2016

The endo fiber optic shape tracker (EFOST) is a novel means of enabling a clinician to track, in real-time, the shape and position of endoluminal surgical instruments (that is, instruments designed to navigate inside of tubular structures, like an artery or intestine) that have been inserted into the body.

Business Thesis: A shape tracking device and navigational aid for peripheral endovascular procedures to reduce costs of catheter/guidewire by $2000 per procedure, increase percentage of endovascular procedures and to increase throughput for endovascular surgeries by at least 1 procedure per week.

EL: Ben Rinehart, MS, Graduate Student, Biomedical, Industrial & Human Factors Engineering, Wright State University
PI: Caroline Cao, PhD, Professor, Biomedical, Industrial & Human Factors Engineering, Wright State University
Mentor: Andrew Cothrel, President, Blue Marble Medical, LLC
Mentor: Sean Barnett, Chief Medical Officer, Kaleidoscope, Inc

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I-Corps 2016

PROTECH Sensors – 2016

A wearable/handheld device for industrial hygienists/safety officers in companies that use or produce petroleum hydrocarbons to detect specific VOCs in real-time to reduce turnaround time and determine the right amount of protective measurements to take.
Business Thesis: Industrial Hygienists/ Safety Officers in companies that use or produce petroleum hydrocarbons need a wearable/handheld device to detect specific VOCs in real-time to reduce turnaround time and determine the right amount of protective measurements to take.

EL: Geethanga de Silva, Doctoral Student, Department of Electrical Engineering and Computing Systems, The University of Cincinnati
PI: Fred R. Beyette Jr., PhD, Professor, Department of Electrical Engineering and Computing Systems, The University of Cincinnati
Mentor: Ronald Meyers, Director of Technology Commercialization, Center for Entrepreneurship & Commercialization, The University of Cincinnati

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I-Corps 2016

Cool-Aid – 2016

The Heat Stress Prevention Kit (HSPK) is a personal device designed to reduce the number of casualties and illness related to extreme environmental exposures.  By conditioning the breathable air before respiration, the HSPK promotes body heat dissipation and therefore aids in the regulation of the body core temperature.

Business Thesis: The HSPK reduces body temperature and heart rate to increase helmet wearer comfort and safety. 2/3 of motorcycle users are willing to pay 10% more for 40oF reduction in helmet temperature.

EL: Harry Harris, Undergraduate Student Aerospace Systems Engineering, The University of Akron
PI: Nicholas Garafolo, PhD, Assistant Professor, Department of Mechanical Engineering, The University of Akron
Mentor: Gopal Nadkarni, Proof-of-Concept Director, Department of Mechanical Engineering, The University of Akron
Mentor: Aaron Rood, Project Manager, Cobham Mission Systems

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Team-19

LnR – 2016

The technology is a metal processing technique that enables the manufacture of precision, thin-walled, hollow extruded profiles from copper and copper alloys.

Business Thesis: We apply our technology to target companies who use copper parts for liquid cooled and heat transfer problems. We offer thin-walled, thermally efficient, precision copper extrusions at lower costs than current solutions.

EL: Kevin Zhang, Market Analyst, TechGROWTH Ohio
PI: Frank F. Kraft, PhD, Professor, Department of Mechanical Engineering, Ohio University
Mentor: Kevin Krizman, Principal, KupferTek

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Team-22

Blue Shift Labs – 2016

Our technology is a high-throughput screening assay to identify protein binding with target RNA or DNA binding proteins.

Business Thesis: BlueShift Labs is a contract research organization offering biomedical researchers and pharma companies the first commercial test to directly detect activity of RNA-binding proteins.

EL: Sarah Anthony, Research Assistant, University of Cincinnati
PI: Mike Tranter, PhD, Assistant Professor, Department of Internal Medicine, Cardiovascular Health and Diseases, University of Cincinnati
Mentor: Grant Hoffman, Professor of Practice – Entrepreneurship, Rose-Hulman Institute of Technology

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Exemplary Lessons Learned

stop-clot

Stop-Clot – 2016

Our product is a small-molecule drug that inhibits select functions of human platelets related to coagulation. The technology includes a method of inhibiting platelets from becoming hypersensitive by administering an effective amount of our product to a patient, which will inhibit platelets in the patient from becoming hypersensitive.

Business Thesis: Cardiologists, neurologists, and primary care physicians will use our compound to prevent clotting in patients who have previously experienced a cardiovascular event. Our compound will decrease associated major bleeding events by 40%, saving the healthcare system approximately $374 million dollars annually.

EL: Leah Wuescher, PhD, Post-doctoral Fellow, Medical Microbiology and Immunology, University of Toledo
PI: Randall Worth, PhD, Associate Professor, Medical Microbiology and Immunology, University of Toledo
Mentor: Brian Genide, VP, Director of Operations, Superior Uniform Sales

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Alternative Outcome

battery

Battery Management – 2016

Lithium ion batteries (LIBs) consist of cells connected in series, and they require an electronic battery management system (BMS) to measure the cell voltages and equalize (EQU) them. Our new hybrid cell voltages and equalize EQU is called the bi-Level EQU (BEQ), because the circuit equalizes at two different voltage levels by dividing the series-connected cells into sections, each consisting of 4 to 8 cells.

Business Thesis: Our Hybrid EQU: 1. Increases the capacity of large LIBs by 14%; 2. Provides close to max. performance at close to minimum cost; 3. Reduces energy losses by 50%; 4. 1.3x cost of passive.

EL: Sandrine Mubenga, Manager, Electrical Engineering, Facilities Department, University of Toledo
PI: Thomas Stuart, Professor Emeritus, EECS Department, University of Toledo
Mentor: Kelly Jezierski, Chemical Engineer

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